Uh.
Go to MissionPoint, there should be some NPC's in there. Click on them, and they'll give you quests.
There's prey all over. Your quests should tell you where you can find most of them.
If its some kind of issue with the game itself, I'd recommend redownloading. Never heard of this kind of issue before. Try waiting in maps some time, or switch dimensions. Older computers may have trouble with spawning more than others, so be patient.
Let me know if these help.
((/moved to Game Help))
